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The most effective pharmacotherapies for addiction treatment include agonist therapies, such as methadone and buprenorphine, for opiate use disorders. Naltrexone, acamprosate, and disulfiram are approved for the treatment of alcohol use disorder. Varenicline and bupropion are used to treat nicotine addiction. Unfortunately, there are no targeted and effective medications for treating cocaine addiction at the present time, due to its complex effect on the central nervous system. Recent advances in medication development for other substance use disorders, such as stimulant addiction, have been examined. Medications can be combined with psychosocial and behavioral treatments as a component of a multimodal approach to addiction treatment.